Antibody Dependent Enhancement (ADE) – UPSC Prelims

  • ADE occurs when the antibodies generated during an immune response recognize and bind to a pathogen, but they are unable to prevent infection.
  • Instead, these antibodies act as a ‘Trojan horse’, allowing the pathogen to get into cells and exacerbate the immune response.
  • Few experts have suggested that anti- SARS-CoV-2 antibodies could exacerbate COVID-19 through ADE.
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