2-deoxy-D-glucose (2-DG) – UPSC Prelims

2-deoxy-D-glucose (2-DG):
  • 2-deoxy-D-glucose (2-DG) is an anti-Covid oral drug.
  • It has been developed by the Institute of Nuclear Medicine and Allied Sciences (INMAS), a lab of DRDO in collaboration with Dr Reddy’s Laboratories(DRL).
How does a 2-DG drug work?
  • The 2-DG comes in powder form in the sachet.
  • It is taken orally by dissolving the powder in water.
  • The drug accumulates in the virus-infected cells.
  • Thereby, prevents virus growth by stopping viral synthesis and energy production.
  • The selective accumulation of the drug in virally infected cells makes this drug unique.
Significance of this drug:
  • The drug helps in the faster recovery of hospitalised patients. Further, it also reduces supplemental oxygen dependence.
  • A higher proportion of patients treated with 2-DG also showed RT-PCR negative conversion in Covid-19 patients.
  • Drugs Controller General of India(DCGI) has approved this drug for emergency use.
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